Proteins

BDNF, human recombinant

P-105-100

Name BDNF, human recombinant
Synonyms Brain-derived neurotrophic factor, Abrineurin
Uniprot ID P23560
Source Human
MW Mature BDNF, Approximately 13.5 kDa, a single non-glycosylated polypeptide chain containing 118 amino acids
Host CHO-based cell line (expressed by QMCF Technology)
Purification Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter
Concentration 1 mg/ml
Buffer PBS pH 7.4
Endotoxine Less than 1EU/mg of protein as determined by LAL method
QC Coomassie-stained SDS-PAGE analysis (Figure 1)
Background BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (UniProt)
Shipping Shipped on dry ice
Storage Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Related Products Monoclonal antibodies against human BDNF. For more information please visit: www.icosagen.com/antibodies, human neural growth factors. For more information about protein production please visit: www.icosagen.ee/services/protein-production
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€840 / 100µg
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Figure 1. Coomassie-stained SDS-PAGE analysis of human BDNF. Lane 1. 2 µg of BDNF (non-reduced); Lane 2. Protein size marker (Blue Protein Ladder Prestained, Naxo 8003) Lane 3. 2 µg of BDNF (reduced).