302-100
Mouse monoclonal antibody to human CDNF
Datasheet as PDF
Figure 1. Western Blot testing of anti-CDNF monoclonal antibody (6G5). Line 1. PageRuler Prestained Protein Ladder (#SM0671 Fermentas); Line 2. Recombinant CDNF expressed into the supernatant of CHO cell culture medium.
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Immunogen
Human CDNF
Immunogen Description
Recombinant human CDNF protein produced using
CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified
from cell culture supernatant
Uniprot ID
Q49AH0
Alternative Names
ARMETL1
Clonality
Mouse monoclonal
Clone
6G5
Class
IgG1
Reactivity
Human, CDNF protein
Application
ELISA, WB
Protocol
ELISA: 1:64 000; WB: 1:4000 Monoclonal antibody working
titer has to be established practically for each particular antigen and assay
format
Purification
Purified by protein G affinity chromatography
Buffer
PBS pH 7.4, with 0.1% sodium azide
Concentration
1 mg/ml
Unit Size
100 µg
Related Products
Mono- and polyclonal antibodies to human CDNF. For
more details www.icosagen.com/antibodies
Shipping
This product is shipped in non-frozen liquid form in
ambient conditions
Storage
Store at – 20 or -70 °C upon receipt. Divide antibody
into aliquots prior usage. Avoid multiple freeze-thaw cycles as product
degradation may result.
Background
CDNF is a trophic factor for midbrain dopamine neurons
in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al.,
2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine
neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA
or MPTP –lesioning it restores the dopaminergic function and prevents
degeneration of dopamine neurons in substantia nigra pars compacta
Refrences
-
Limitations
This product is for research use only
